Between 1942 and 1946, a team of scientists was assembled in the United States to work on a special military assignment : the production of the first atomic bomb. This endeavour was codenamed The Manhattan Project.
Starting with that premise, comic book creator Jonathan Hickman asked himself this simple question : what if this mission was only the tip of the iceberg? What if this rag-tag group of military and scientific personnel had a greater (bat-sh*t crazy) purpose?
It is from this premise that The Manhattan Projects was born. And the rest, as they say, is (alternate) history.